The cees dekker Diaries
The cees dekker Diaries
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Rotary motion of DNA rotors on nanopores. Major row: raw video of your Cy5 channel of every rotor. Middle row: corresponding solitary-particle localization results of both equally ends of your DNA rotors. The placement of the present frame is marked as orange and blue dots, as well as trajectory of the 10 frames right before The present body is proven as good traces.
1996, initial mesoscopic cost density waves equipment; and initial electrical measurements on one metallic nanocluster amongst nanoelectrodes
Multicolor imaging of your bacterial nucleoid and mobile division proteins with blue, orange, and around-infrared fluorescent proteins
Our function was swiftly followed up by Other folks, most notably by Phaedon Avouris and colleagues at IBM, who in Oct 1998 released their conclusions on transistors comprised of one- and multi-walled carbon nanotubes in Used Physics Letters.
This yielded a breakthrough. In only a few months, we ended up capable of evaluate transport as a result of a person one-walled carbon nanotube. Determined by low-temperature experiments by an excellent PhD student in my team, Sander Tans (now a valued colleague and professor at Delft College of Technological innovation with an Energetic research lab at AMOLF in Amsterdam), we showed that carbon nanotubes were being authentic quantum wires with very prolonged (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic behaviour.
Microbiology has only been around for the century, considering the fact that we began to examine micro-organisms additional very seriously. I assumed nanobiology was an appropriate term, simply because all molecular biological related interactions take place on the nanoscale: a protein is a number of nanometres in dimensions, DNA is two nm thick.’
We use nanofabricated microfluidic constructions to pattern spatial boundaries for germs ceesdekker and biomimetic vesicles with reconstituted protein networks and this assess the elemental job of spatial confinement within the molecular and mobile stage. Our initiatives include things like the next:
Dynamic ParB–DNA interactions initiate and sustain a partition condensate for bacterial chromosome segregation
What if, in place of employing conventional top rated-down silicon electronics, transistors could possibly be built from the bottom up using solitary organic molecules since the switching elements? This concept, which turned The idea of now’s area of molecular electronics, to start with emerged inside the nineteen seventies.
Resolving the phase dimensions in condensin-pushed DNA loop extrusion identifies ATP binding since the phase-creating method
FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division
Afterwards we spoke once again briefly for the reason that Dekker felt that our discussion of his faith speedily turned purely philosophical, Whilst Additionally, it concretely aids him in his get the job done.
Developments in nanotechnology while in the nineties manufactured making Digital products from solitary molecules a probability. Cees Dekker recounts how his staff made a place-temperature transistor based upon only one carbon nanotube.
Supercoiling-dependent DNA binding: quantitative modeling and programs to bulk and single-molecule experiments